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I dont fing care: In wooing $67M from big alcohol, NIH nixed critical study

Koob was dismissive of any conflicts of interest at the time, however, telling the Times: “This study could completely backfire on the alcoholic beverage industry, and they’re going to have to live with it. The money from the Foundation for the NIH has no strings attached.” But the links and the funding didn’t sit well among the research community, who are all too aware that industry-sponsored research often ends up favoring the interests of industry. Many also noted weaknesses in the study's design, including the short duration that limited “moderate” drinking to one drink rather than the more common two and lumped men and women’s health assessments together. In a subsequent story in Wired from October, researchers again expressed concern, with alcohol researcher Jürgen Rehm of Toronto’s Centre for Addiction and Mental Health telling the magazine that "the way this is set up, it smells." The Wired article also noted that Koob and NIAAA Director of Global Alcohol Research Margaret (Peggy) Murray both appeared in a promotional video for Anheuser-Busch InBev, one of the MACH funders, as the NIAAA was setting up for the trial. The video was about company-sponsored research. The situation looked even more ethically dubious after a follow-up report in The New York Times published March 17 of this year. Based on emails and travel vouchers obtained through a Freedom of Information Act request, as well as interviews, the Times reported that the NIAAA “waged a vigorous campaign” to pursue industry funding in 2013 and 2014. This involved having scientists schmooze with industry executives at meetings and lunches, allowing executives to preview the trial design and vet researchers who strongly suggested the study would end in their favor. Kenneth Mukamal, of Harvard Medical School and now lead investigator of the MACH trial, along with John Krystal, a Yale University neuroscientist, forcefully pitched the trial as being able to dispel concerns about moderate, daily drinking. And their pitch was followed up with NIAAA officials who urged them to financially support the study. “A definitive clinical trial represents a unique opportunity to show that moderate alcohol consumption is safe and lowers risk of common diseases,” one of the scientists’ slides read. “That level of evidence is necessary if alcohol is to be recommended as part of a healthy diet.” “We have strong reason to suspect so,” another slide read, referring to the previous research linking moderate alcohol to reduced risks of cardiovascular disease. The Times concluded that its efforts may have violated NIH policies, which prevent employees from soliciting funds, donations, or other resources to support NIH activities. The NIH is now investigating whether that was the case.

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